For some years the big drugmakers have been worrying about an approaching "patent cliff"—a fall in sales as the patents on their most popular pills expire or are struck down by legal challenges, with few new potential blockbusters to take their place. This week the patent on the best-selling drug in history expired—Lipitor, an anti-cholesterol pill which earned Pfizer nearly $11 billion in revenues last year.In all, pill like Lipitor with a combined $170 billion in annual sales will go off-patent by the end of 2015.
What is supposed to happen now is that lots of copycat firms rush in with "generic" (ie, chemically identical) versions of Lipitor at perhaps one-fifth of its price.Patients and health-care payers should reap the benefit.Pfizer's revenues should suffer. The same story will be repeated many times, as other best-selling drugs march over the patent cliff
But generics makers may face delays getting their cheaper versions to market.Ranbaxy, a Japanese-owned drugmaker, struggled to get regulators' approval for its generic version of Lipitor, and only won it on the day the patent expired.More importantly, research-based drug firms are using a variety of tactics to make the patent cliff slope more gently. Jon Leibowitz, chairman of America's Federal Trade Commission (FTC), is concerned by drugmakers filing additional patents on their products to put off the day when their protection expires.
Another tactic(策略) is "pay-for-delay", in which a drugmaker facing a legal challenge to its patent pays its would-be competitor to put off introducing its cheaper copy. In the year to October the FTC identified what it believes to be 28 such settlements. American and European regulators are looking into these deals. However, legal challenges against them have been delayed, and a bill to ban them is stuck in Congress.
To encourage generics makers to challenge patents on drugs, and introduce cheaper copies,
an American law passed in 1984 says that the first one to do so will get a 180-day exclusivity period,in which no other generics maker can sell versions of the drug in question, as Ranbaxy supposedly won with Lipitor.
However, Pfizer is exploiting a loophole(空子) in the 1984 law, which lets it appoint a second, authorised copycat—in this case, Watson, another American firm.According to BernsteinResearch, under the deal between the two drugmakers Pfizer will receive about 70% of Watson's revenues from its approved copy of Lipitor.More unusual, Pfizer has cut the price of its original version, and will keep marketing it vigorously. So Ranbaxy faces not one, but two competitors.
All this may raise Pfizer's sales by nearly $500m in the last half of 2015 compared with what they would otherwise have been, says Tim Anderson of BernsteinResearch, with revenues then falling after the 180 days are over. Others fear that Pfizer's tactics , if copied, will make the 180-day exclusivity period worth far less, and thus discourage generic firms from challenging patents in the first place.The underlined word “blockbusters” in Paragraph 1 refers to “_______’
| A．pills that sell very well |
| B．new patents to appear |
| C．drugmakers to compete with Pfizer |
| D．challenges which Pfizer has to face |
What is the tactic mentioned in Paragraph 4?
| A．Legal challenges against expired patents have been paid for putting off the cheaper copy. |
| B．Bills to prohibit generic makers have been stuck in Congress. |
| C．Drugmakers try to spend money delaying filing additional patents on popular pills |
| D．Patent-holders give possible competitors money to prevent more losses. |
Pfizer exploit a loophole in the 1984 law mainly by ________.
| A．marketing Lipitor more actively |
| B．making the price of Lipitor go up |
| C．cooperating with Watson to beat Ranbaxy |
| D．encouraging Watson to produce cheaper copies |
How many tactics are adopted by patent-holders in the passage?
| A．Two | B．Three | C．Four | D．Five |
Which of the following might be the best title for the passage?
| A．Drugmakers’ struggle |
| B．Generic makers’ dilemma |
| C．Laws concerning patent protection |
| D．Popular pills of Pfizer |
How often do you sit still and do absolutely nothing? The usual answer these days is“never” or “hardly ever”. As the pace of life continues to increase, we are fast losing the art of relaxation. Once you are in the habit of rushing through life, being on the go from morning till night, it is hard to slow down. But relaxation is essential for a healthy mind and body.
Stress is a natural part of everyday life. There is no way to avoid it, since it takes many and varied forms-driving in traffic, problems with personal relationships are all different forms of stress. Stress, in fact, is not the “baddy” it is often reputed to be. A certain amount of stress is vital to provide motivation and give purpose to life. It is only when the stress gets out of control that it can lead to poor performance and ill health.
The amount of stress a person can withstand depends very much on the individual. Some people are not afraid of stress, and such characters are obviously prime material for managerial responsibilities. Others lose heart at the first sight of unusual difficulties. When exposed to stress, in whatever form, we react both chemically and physically. In fact we make a choice between “fight” or “fright” and in more primitive days the choice made the difference between life and death. The crisis we meet today are unlikely to be so extreme, but however little the stress, it involves the same response. All the energy is shifted to cope with the stress. It is when such a reaction lasts long, through continued exposure to stress, that health becomes endangered. Such serious conditions as high blood pressure and heart disease have established links with stress.
Stress in some people produces stomach disorders, while others experience tension headaches. Since we cannot remove stress from our 1ives, We need to find ways to cope with it.People are finding less and less time for relaxing themselves because .
| A．they are working harder than they used to |
| B．they are often too busy to find the time |
| C．they are not clear of how to relax by themselves |
| D．they are suffering from the effects of stress |
What is implied but not stated in the passage?
| A．The art of relaxation can greatly help people bear stress. |
| B．People in primitive days know certain ways to deal with stress. |
| C．If one gets into the habit of relaxing every day he can overcome stress easily. |
| D．Stress can lead to serious health problem if one is exposed to it for too long. |
The underlined sentence in Paragraph 2 suggests that .
| A．stress is not always a bad thing for people |
| B．stress has a bad reputation of causing ill health |
| C．stress is not so terrible as people often believe it to be |
| D．stress is always harmful to people all the time |
According to this passage, which of the following statements is true?
| A．Relaxation in life only benefits us mentally. |
| B．Different people can stand different amounts of stress. |
| C．All the stress can lead to poor performance. |
| D．Large amounts of stress is important to people's lire. |
What is the writer's attitude to stress according to the passage?
| A．Stress as well as relaxation is essential for a healthy mind and body. |
| B．Stress should not be rid completely from the life. |
| C．Stress produces both positive and negative effects on people. |
| D．People usually work better under stress if they are healthy. |
A baby born in India has been declared the world's seven billionth person by child rights group Plan International. Baby Nargis was born at 07:25 local time (01:55GMT) in Mall village in India's Uttar Pradesh state. Plan International says Nargis has been chosen symbolically as it is not possible to know where exactly the seven billionth baby is born. In addition to baby Nargis in India, Bangladesh, the Philippines and Cambodia have all identified seven billionth babies. The United Nations estimated that on Monday 31 October, the world's population would reach seven billion.
Populations are growing faster than economies in many poor countries in Africa and some in Asia. At the same time, low birth rates in Japan and many European nations have raised concerns about labor shortages.
Population experts at the United Nations estimated that the world reached six billion in October 1999. They predict nine billion by 2050 and ten billion by the end of the century. China's population of one and a third billion is currently the world's largest. India is second at 1.2 billion. But India is expected to pass China and reach one and a half billion people around 2025.
India will also have one of the world's youngest populations. Economists say this is a chance for a so-called demographic dividend. India could gain from the skills of young people in a growing economy at a time when other countries have aging populations. But economists say current rates of growth, although high, may not create enough jobs. Also, the public education system is failing to meet demand and schooling is often of poor quality. Another concern is health care. Nearly half of India's children under the age of five are malnourished(营养不良).
Michal Rutkowski, the director of human development in South Asia at the World Bank, says reaching seven billion people in the world is a good time for a call to action. He says, “I think the bottom line of the story is that the public policy needs to become really, really serious about sex equality and about access to services—to fight against malnutrition, and to provide for access to health services, water and schooling.”What is true about the world's seven billionth person?
| A．Baby Nargis is not the only child chosen as the seven billionth baby. |
| B．Baby Nargis has been chosen carefully so it is exactly the seven billionth baby. |
| C．Three countries have all declared Baby Nargis as the seven billi011th baby. |
| D．The United Nations declared Baby Nargis as the world's seven billionth person. |
Which of the following problems do many European countries worry about?
| A．Labor shortage. | B．Poor health care. |
| C．Not enough jobs. | D．Schooling of poor quality. |
According to population experts, how long will it take for population to grow from six billion to nine billion?
| A．About 12 years. | B．About 40 years. | C．About 50 years. | D．About 110 years. |
What does the underlined phrase “demographic dividend” in the fourth paragraph refer to?
| A．Possibility of lower birth rate. |
| B．Benefit gained by working young people. |
| C．Chances for more employment. |
| D．Disadvantages caused by aging population. |
Which of the following public policies does Michal Rutkowski call on?
| A．To encourage late marriage. | B．To reduce world's population. |
| C．To gain economic equality. | D．To improve health and education. |
"Oh, you must have been a spoiled(宠坏的) kid. You must be really bossy. I wonder what you're going to be like to deal with?" That's often the response Angela Hult gets when people find out she's an only child, she told ABC News, Despite such negative(消极的) remarks, Hult has decided to have only one child herself. And she's not alone.
According to the US' Office for National Statistics, women approaching the end of their childbearing years had an average of l.9 children in 2004, compared with 3.1 for their counterparts in 1976. The percentage of one-child families in Britain had risen from 18 percent in 1972 to 26 percent in 2007.
But even though only children are becoming increasingly common, the traditional view that they're selfish, spoilt and lack social skills holds strong. Even parents of only children, like Hult, are made to feel guilty about having only one child. Worried that they're being selfish and endangering their child's future, they flock to online discussion forums seeking advice. Soon, however, they ask themselves: is this social prejudice really reasonable?
"There have been hundreds and hundreds of research studies that show that only children are no different from their peers(同龄人) ," Susan Newman, a social psychologist at Rutgers University in the US, told ABC News.
This raises another question: why are only children still viewed with such suspicion?
"There is a belief that's been around probably since humans first existed that to have just one child is somehow dangerous, both for you and for the continuation of your race," Toni Falbo, a professor of educational psychology, told the Guardian." In the past a lot of children died, You'd have had to be crazy to only have one. "
Times, of course, have changed and infant mortality(婴儿死亡率) has largely reduced. So what do only children themselves say?
Kayley Kravitz, a blogger for The Huffington Post, grew up as an only child and highly recommends the experience. "Being an only child taught me the most valuable skill of all: the ability to be alone," she said.Which of the following could be the best title for the text?
| A．Are only children lonely? |
| B．Are only children common? |
| C．Are only children dangerous? |
| D．Are only children different? |
What does Susan Newman mean?
| A．Only children are as good as their peers. |
| B．Only children are more selfish and spoiled. |
| C．Parents feel guilty about having only one child. |
| D．Parents will endanger their only child's future. |
What is the common belief since human existed?
| A．The infant death rate always stays high. |
| B．People are crazy to have only one child. |
| C．It's easy for only children to earn their living. |
| D．It's hard to continue the family line with only one child. |
An only child like Kayley _______.
| A．must be difficult to persuade |
| B．can possibly learn to be alone |
| C．should value special skills |
| D．need ignore bad experience |
What's the author's attitude towards having only one child?
| A．Neutral. | B．Negative. | C．Positive. | D．Doubtful. |
In America, Virginia Beach has all the elements of a classic seaside resort: brilliant beaches, a lively boardwalk, plenty of restaurants and nightspots, and amusement rides are sure to appeal to kids. Many believe Virginia Beach is at its best in the off-season, when the town is less crowded but the weather is still mild.
Meanwhile, some safety tips should be followed, enjoying the happiness and excitement the beach offers.
The number l safety tip concerns ocean safety: pay attention to Flag conditions posted on the lifeguard stands. Lifeguards post a red flag to warn when the ocean water is dangerous. Take them seriously! Tourists from land-locked regions are particularly easily attracted by the magic of the waves. However, a calm ocean can become risky without warning. Make sure you swim near a lifeguard. Swimming without lifeguard protection is almost five times as great as drowning at a beach with lifeguards.
Never swim alone. Many drownings involve single swimmers. When you swim with someone else, if one of you has a problem, the other may be able to get help, including signaling for assistance from others.
Don't fight the current. The facts show that some 80% of rescues by lifeguards at ocean beaches are caused by currents. These currents are formed by surf and gravity, because once surf pushes water up the slope of a beach, gravity pulls it back. This can create concentrated rivers of water moving offshore. If you are caught in a rip current, don't fight it by trying to swim directly to shore. Instead, swim parallel to shore until you feel the current relax, then swim to shore. Most rip currents are narrow and a short swim parallel to shore will help bring you to safety.When coming to Virginia Beach, children can enjoy the happiness of .
| A．walking on the road made of wood | B．joining the nightspots |
| C．having interesting rides | D．skiing in the sea |
Many people believe the best time to visit Virginia Beach may be .
| A．after autumn school term beginning | B．in the slimmer vacation |
| C．during the Christmas holiday | D．in the cold winter |
Swimming in the sea you'd better not swim .
| A．with a friend | B．within the sight of the lifeguard |
| C．with the current | D．as far as you like |
From the passage, we can know .
| A．one in five persons swimming in the sea is drowned |
| B．if one with lifeguard were drowning, five persons without lifeguard would be |
| C．some 80% people drowning by the currents are rescued by lifeguards |
| D．some 20% drowning by the currents are rescued by life guards |
The passage mainly tells us .
| A．some safety tips when swimming in the sea |
| B．the happiness and excitement the beach offers |
| C．Virginia Beach has all the elements of a classic seaside resort |
| D．the dangers for tourists from land-locked regions to swim in the sea |
A few degrees can make a big difference when it comes to food storage. Foods can go bad if they get too warm. But for many of the world’s poor, finding a good way to keep food cool is difficult. Refrigerators are costly and they need electricity.
Yet spoiled food not only creates health risks but also economic losses. Farmers lose money when they have to throw away products that they cannot sell quickly.
But in nineteen ninety-five a teacher in northern Nigeria named Mohammed Bah Abba found a solution. He developed the “Pot-in-Pot Preservation/Cooling System.” It uses two round containers made of clay. A smaller pot is placed inside a larger one. The space between the two pots is filled with wet sand. The inner pot can be filled with fruit, vegetables or drinks. A wet cloth covers the whole cooling system.
Food stored in the smaller pot is kept from spoiling through a simple evaporation(蒸发) process. Water in the sand between the two pots evaporates through the surface of the larger pot, where drier outside air is moving.
The evaporation process creates a drop in temperature of several degrees. This cools the inner pot and helps keep food safe from harmful bacteria. Some foods can be kept fresh this way for several weeks.
People throughout Nigeria began using the invention. And it became popular with farmers in other African countries. Mohammed Bah Abba personally financed the first five thousand pot-in-pot systems for his own community and five villages nearby.
In two thousand, the Rolex Watch Company of Switzerland honored him with the Rolex Award for Enterprise. This award recognizes people trying to develop projects aimed at improving human knowledge and well-being. A committee considers projects in science and medicine, technology, exploration and discovery, the environment and cultural history. Winners receive financial assistance to help develop and extend their projects.Which is the best title of the passage?
| A．A Few Degrees can Make a Big Difference for Storage |
| B． A Cool Way to Keep Food from Spoiling |
| C． Spoiled Food Creates Health Risks and Economic Losses |
| D． The Evaporation Process Creates a Drop in Temperature |
What does the third paragraph mainly talk about?
| A．the structure of the invention |
| B．the usage of the invention |
| C．the cost of the invention |
| D．the inspiration of the invention |
What is it that essentially keeps the food in the container from spoiling?
| A．the wet cloth covering the cooling system. |
| B．the moving drier air outside the container |
| C．the wet sand between the containers |
| D．a drop in temperature by evaporation |
According to the passage, where can we possibly see the invention?
| A．rich and advanced families |
| B．scientific experiment laboratory |
| C．poor and underdeveloped area |
| D．supermarket needing to store goods |
We can know from the passage that Mohammed Bah Abba ____________.
| A．invented the controversial cooling system |
| B．financed the systems in all communities |
| C．received financial assistance for his invention |
| D．invented more complicated cooling system later |
粤公网安备 44130202000953号