For some years the big drugmakers have been worrying about an approaching "patent cliff"—a fall in sales as the patents on their most popular pills expire or are struck down by legal challenges, with few new potential blockbusters to take their place. This week the patent on the best-selling drug in history expired—Lipitor, an anti-cholesterol pill which earned Pfizer nearly $11 billion in revenues last year.In all, pill like Lipitor with a combined $170 billion in annual sales will go off-patent by the end of 2015.
What is supposed to happen now is that lots of copycat firms rush in with "generic" (ie, chemically identical) versions of Lipitor at perhaps one-fifth of its price.Patients and health-care payers should reap the benefit.Pfizer's revenues should suffer. The same story will be repeated many times, as other best-selling drugs march over the patent cliff
But generics makers may face delays getting their cheaper versions to market.Ranbaxy, a Japanese-owned drugmaker, struggled to get regulators' approval for its generic version of Lipitor, and only won it on the day the patent expired.More importantly, research-based drug firms are using a variety of tactics to make the patent cliff slope more gently. Jon Leibowitz, chairman of America's Federal Trade Commission (FTC), is concerned by drugmakers filing additional patents on their products to put off the day when their protection expires.
Another tactic(策略) is "pay-for-delay", in which a drugmaker facing a legal challenge to its patent pays its would-be competitor to put off introducing its cheaper copy. In the year to October the FTC identified what it believes to be 28 such settlements. American and European regulators are looking into these deals. However, legal challenges against them have been delayed, and a bill to ban them is stuck in Congress.
To encourage generics makers to challenge patents on drugs, and introduce cheaper copies,
an American law passed in 1984 says that the first one to do so will get a 180-day exclusivity period,in which no other generics maker can sell versions of the drug in question, as Ranbaxy supposedly won with Lipitor.
However, Pfizer is exploiting a loophole(空子) in the 1984 law, which lets it appoint a second, authorised copycat—in this case, Watson, another American firm.According to BernsteinResearch, under the deal between the two drugmakers Pfizer will receive about 70% of Watson's revenues from its approved copy of Lipitor.More unusual, Pfizer has cut the price of its original version, and will keep marketing it vigorously. So Ranbaxy faces not one, but two competitors.
All this may raise Pfizer's sales by nearly $500m in the last half of 2015 compared with what they would otherwise have been, says Tim Anderson of BernsteinResearch, with revenues then falling after the 180 days are over. Others fear that Pfizer's tactics , if copied, will make the 180-day exclusivity period worth far less, and thus discourage generic firms from challenging patents in the first place.The underlined word “blockbusters” in Paragraph 1 refers to “_______’
| A．pills that sell very well |
| B．new patents to appear |
| C．drugmakers to compete with Pfizer |
| D．challenges which Pfizer has to face |
What is the tactic mentioned in Paragraph 4?
| A．Legal challenges against expired patents have been paid for putting off the cheaper copy. |
| B．Bills to prohibit generic makers have been stuck in Congress. |
| C．Drugmakers try to spend money delaying filing additional patents on popular pills |
| D．Patent-holders give possible competitors money to prevent more losses. |
Pfizer exploit a loophole in the 1984 law mainly by ________.
| A．marketing Lipitor more actively |
| B．making the price of Lipitor go up |
| C．cooperating with Watson to beat Ranbaxy |
| D．encouraging Watson to produce cheaper copies |
How many tactics are adopted by patent-holders in the passage?
| A．Two | B．Three | C．Four | D．Five |
Which of the following might be the best title for the passage?
| A．Drugmakers’ struggle |
| B．Generic makers’ dilemma |
| C．Laws concerning patent protection |
| D．Popular pills of Pfizer |
370 S. Perry St., Denver, Colorado
Price: $164,500 For sale by: Resale Homes by Owner
Bedrooms: 3 Bathroom: 1 Garage: 1
Square Feet: l, 003 Lot Size: 2
Year Built: —
School District: —
Open House Date: —
Open House Time: —
Date Posted: January 21, 2007
Best value in Denver: This Garden style home is equipped with a grape vine that wraps around the front of the house. There is a small-unfinished basement, attic (阁楼) and an additional room in the garage. It is zoned (划成区域) R2 (two families can live here) and positioned at the back of the double sized lot (plenty of room to build) It is fully landscaped (美化) with sprinkler (洒水装置) system and privacy (独处而不受干扰) fence. It is 5 minutes from downtown. The neighbors are great, and security is good. Viewing anytime.
Home Features: Carpeted Floors ● Dishwasher ● Patio
Community Features: Public Transportation ● Wheelchair Access
64. If one dollar equals 8 Yuan, one square feet equals 0.093 square meters, how much does one square meter of the house cost?
A. About 15,140 Yuan. B. About 13,120 Yuan.
C. About 13,160 Yuan. D. About 14,150 Yuan.
65. During summer time, the front of the home may look _________.
A. green B. White C. red D. black
66. Which of the following statements about the house is NOT true?
A. You will spend extra money to build a room in the garage after buying the house.
B. You can have enough room to enlarge your house after you buy it.
C. You don’t need to water the plants in the garden by yourself.
D. If you buy the house, you can also have the dishwasher and carpet.
67. What does the “Wheelchair Access” probably mean?
A. It’s a kind of sidewalk built for disabled people.
B. It’s an entrance to a house built for the disabled people.
C. It’s a street built for the disabled people to have a walk.
D. It’s a special path for the disabled people to get to the garage.
Failure is probably the most fatiguing (令人疲劳的)experience a person ever has. There is nothing more tiring than not succeeding, being blocked, not moving ahead. It is an evil circle. Failure causes fatigue, and fatigue makes it harder to get to work, which adds to the fatigue.
We experience this tiredness in two main ways: start-up fatigue and performance fatigue. In the former case, we keep putting off a task that we are forced to take up. Either because it is too boring or because it is too difficult, we avoid it. And the longer we put it off, the more tired we feel.
Such start-up fatigue is very real, even not actually physical, not something in our muscles and bones. The remedy (治疗法) is obvious, though perhaps not easy to apply: willpower exercise. The moment I find myself turning away from a job, or putting it under a pile of things I have to do, I clear my desk of everything else and attack the difficult item first. To prevent start-up fatigue, always treat the most difficult job first.
Performance fatigue is more difficult to handle. Here we are willing to get started, but we can't seem to do the job right. Its difficulties appear to be insurmountable and however hard we work, we fail again and again. The mounting experience of failure carries with it an ever-increasing burden of mental fatigue. In such a situation, I work as hard as I can, then let the unconsciousness take over.
72.. Which of the following can be called an evil circle？
A. Success-zeal-success-zeal.
B. Failure-tiredness-failure-tiredness.
C. Failure-zeal-failure-tiredness.
D. Success-tiredness-success-tiredness.
73.. According to the passage , when keeping putting off a task, we can experience _______.
A. tiredness B. performance fatigue C. start-up fatigue D. unconsciousness
74.To overcome start-up fatigue, we need ________ .
A. toughness B. prevention C. muscles D. strong willpower
75.. The underlined word "insurmountable" in the last paragraph probably means ________ .
A. that can not be overcome B. that are known
C. that can not be imagined D. that can not be objected
If you want to be a success, study at the University of Waikato is right for you. The university is internationally recognised for its excellence and achievements. It will help you develop advanced research skills. As a university student you can get first-class research facilities (设施) with trained teachers to help, support and advise you in your study. We pride ourselves on our high standards, our research success and our international recognition. For further information: inf@waikato.ac.nz
Degree
We offer a wide choice of bachelor’s degrees for international students, which includes: Arts, Communication Studies, Social Sciences, etc. Bachelor of Music and Bachelor of Education are only for New Zealand citizens, for further information: deg@waikato.ac.nz
Tuition Fees(学费)
Tuition fees are different from department to department, generally from $5,000 to $6,000 a year. For further information: tui@waikato.ac.nz
Accommodation(住宿)
You can have a room in a 4-bedroom flat, which will cost about $100 a month with other regular living costs of about $150 a month for one person. For further information: acc@waikato. ac.nz
Health
The Student Health Service provides excellent medical services for students. The Medical Centre is open five days a week, including student holidays with four doctors and nurses to meet your medical needs. For further information: heal@waikato.ac.nz
Sports
The Centre is a great place to have sports activities. Trained exercise teachers can help you work out a training plan and keep you active. The sports hall has volleyball, basketball and indoor football courts and a swimming pool as well. There are also a large number of sports clubs at Waikato. For further information: sport@ waikato.ac.nz
68.. If you want to get more information about arts, you can write to ______.
A. sport@waikato.ac.nz B. heal@waikato.ac.nz
C. deg@waikato.ac.nz D. inf@waikato.ac.nz
69.. You have to pay at least ______ a year if you study at the University of Waikato.
A. $5,250 B. $8,000 C. $9,000 D. $11,000
70.. According to the text, what will you do if you are ill during Christmas holidays?
A. Go to a hospital nearby.
B. Buy some medicine in a drug store.
C. See a doctor at the school medical centre.
71.. Try to get help from your classmates.
For more than twenty years scientists have been searching for signs of life on other planets. Most of these searches have been done over the radio. The hope is that someone in outer space may be trying to get in touch with us. Scientists also have sent radio and television messages on spaceships travelling through space, on the chance that someone may be receptive to such message.
Scientists are using powerful radio telescopes to listen to signals from about 1,000 stars, all within 100 light years of Earth. In addition, they will scan the entire sky to "listen" for radio messages from more distant stars. Using a computer, they will be able to monitor more than eight channels at one time. Scientists are looking for any signal that stands out from the background noise.
Of the 200 billion stars in the Milky Way galaxy, scientists find that five percent are like our sun. Perhaps half of them have a planet like Earth. Such a planet would be a reasonable distance from the star for temperatures to be right for the evolution (进化) of life. Based on the inhabitable (that can be lived in) planets in our galaxy, most scientists agree that chances are likely that one or more of these planets support some life.
However, many scientists wonder whether intelligent life exists on other planets. Some believe that twenty years of searching without any intelligible messages shows that no one is out there. They say that the evolution of intelligence comparable to ours is unlikely.
Other scientists believe that our search hasn’t been long enough to rule out the possibility that intelligent life exists in our galaxy. Although our sun family is only about five billion years old, our galaxy is about 20 billion years old. In that time, some scientists think it is likely that civilization much more advanced than ours have developed. Perhaps these civilizations send us no signals; perhaps we have not recognized the signals they have sent us. If we hope to find intelligent life, these scientists believe that we have to keep looking.
64. According to the passage, how many planets in our galaxy might be inhabitable?
A. 5 billion B. 10 billion C. 15 billion D. 200 billion
65.. The first paragraph in this passage is mainly about _____.
A. how scientists are looking for signs of life on other planets
B. why scientists are looking for signs of life on other planets
C. where scientists are looking for signs of life on other planets
D. When scientists are looking for signs of life on other planets
66.. The underlined word “ monitor” in Paragraph 2 means “_______”.
A. find B. follow C. check D. form
67.. Which of the following is TRUE based on the information in the passage?
A. The earth is the oldest planet in our galaxy.
B. All scientists believe that there is intelligent life on other planets.
C. Scientists are trying different ways to find signs of life on other planets.
D. Scientists will give up the search for signs of life on other planets.
A simple piece of clothesline hangs between some environmentally friendly Americans
and their neighbors．
On one side stand those who see clothes dryers(干衣机)as a waste oi energy and a
major polluter of the environment．As a result，they are turning to clotheslines as part of the
“what—l—can—do environmentalism(环境保护主义)．”On the Other side a．re people who
are against drying clothes outside，arguing that clotheslines are unpleasant tn look at。They
have Dersuaded Homeowners Associations (HOAs) access the U．S．to ban outdoor
clotheslines，because clothesline drying also tends 10 lower home value in the neighborhood．
This has led to a’Right—to--Dry Movement that is calling for laws to be passed to protect
people’s right tO use clotheslines．So far，only three states have laws to protect clotheslines．
Right—Lo—Dry supporters argue that there should be more．
Matt Reck，37，is the kind of eco—conscious(有生态意识的)person who feeds his trees
with halhwal er and reuses water drops from his air conditloners to water plants．His family
also uses a clothesline．But on July 9，2007，the itOA in Wake Forest，Norlh Ca rolina．told
him that a dissatisfied neighbour had telephoned them about hi
s clothesline．The Recks paid
no attention tO the warning and still dri'ed their clothes on a
line in the yard．“Many people
say they are environmentally friendly but they don’t take matters in their own hands。”says
Reck．The local HoA has decided not tO take any action，unless more neighbors co~le 10
them．
North Carolina lawmakers are saying that banning clotheslines is not the right thing to
do．But HO
As and housing businesses believe that clothesline drying reminds people o
f poor
neighborhoods．They worry that if buyers think their future neighbors can’t even afford
dryers，housing prices will fall．
Environmentalists say such worries are not necessary，and in view of global warming，
that idea needs to change．As they say，“The clothesline is beautiful”．Hanging clothes
outside should be encouraged．We a11 have to do at least something to slow down the process
of glohal warming．
60．One of the reasons why supporters of clothes dryers are trying to ban clothesline drying
iSthat
A．clothes dryers are more efficient
B．clothesline drying reduces home value
C．clothes dryers are energy--saving
D．clothesline drying is not allowed in nlost U．S．slates
61．Which of the following best describes Matt Reck?
A．He is a kind～hearted man． B．He is an impolite man．
C．He is an experienced gardener． D．He is a man of social responsibility
62．Who are in favor of clothesline drying?
A．Housing busmesses． B．Environmentalists．
C．Homeowners Associations． D．Reck’8 dissatisfied neighbors．
63．What is mainly discussed in the text?
A．Clothesline drying：a way to save energy and fnnRey
B．Clot hesline drying：a lost art rediscovered．
C．Opposite opinions on clothesline drying．
D．Different varieties of clotheslines．
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