Whencomestoresearchintoheartdi

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When ______ comes to research into heart disease and its effects on the body, we do not have adequate substitutes for the use of animals.

A．that

B．it

C．this

D．what

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— You seem to be on top of the world.
— Of course. There’s more exciting than seeing your name in print.

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C．nothing

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—I'm sorry. I didn't spill the juice on your clothes on purpose.
—

A．Don't mention it.

B．How come?

C．So what?

D．Go ahead.

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— How would you like your coffee? —______ .

A．It' s well done

B．The stronger, the better

C．One cup. That's enough

D．Very nice. Thank you

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____ after a long walk, Henry called me and said he couldn’t come to the meeting.

A．Having worn out	B．Being worn out
C．To wear out	D．Worn out

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I just wonder _______that upsets him so much.

A．what it is

B．what he does

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